Analysis of Common Mutation of P53 Gene in Male with Lung Cancer in Mosul City

TP53 gene plays a critical role in the follow-up of different cancer cases, including diagnosis and treatment mutation P53 gene. It harms encoded protein less function types due to has many mechanisms eliminate cells, like apoptosis, cell cycle arrest, DNA repair. This study aims detect abnormality change sequence correlation with Mosul city extraction depends on manual description from blood, Pro72Arg exon 4 G\C allele measurement by ARMS-PCR, analysis common Exon 3,4,5 sequencing technique. The result this shows observation genotypes allelic frequencies polymorphism 4. was presence wild-type genotype CC (pro\pro) 12%, hetero CG (pro\arg) 72% mutant GG (arg\arg) 16% patients Lung cancer. While healthy people, wild 26 66 8%. As for sequencing, research doesn't find any nucleotide 5 case study. At same time, 6 finds some changes sequence. According study, frequency present significant variation between lung group male Keywords: gene, Mutation, SNP, cancer, Exon.